What is Case It?

Case It is a project providing a framework for collaborative case-based learning via free, open-ended molecular biology simulations (see below) and cases based primarily on genetic and infectious disease.  The project has been supported by the University of Wisconsin-River Falls and funded by the National Science FoundationCase It t won a Science Prize from AAAS for its effectiveness as a tool for inquiry-based instruction, as described in the essay published in Science magazine.  Supplementary materials published with the essay provide suggestions for class use.

Case descriptions are in the student version of the Resource Manual, with associated DNA and protein sequences included in the download package.  Contact Mark Bergland for access to the Instructor’s version of the Resource manual, which includes keys to cases and other information on case development and class use.

Case It v7 ( coming soon)


*Tamura K, Dudley J, Nei M & Kumar S 2007. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Molecular Biology and Evolution 24:1596-1599.

**Dereeper A., Guignon V., Blanc G., Audic S., Buffet S., Chevenet F., Dufayard J.-F., Guindon S., Lefort V., Lescot M., Claverie J.-M., Gascuel O. Phylogeny.fr: robust phylogenetic analysis for the non-specialist Nucleic Acids Research. 2008 Jul 1; 36 (Web Server Issue):W465-9. Epub 2008 Apr 19. (PubMed)

***MAFFT v7 © 2013 Kazutaka Katoh

****Acknowledgements for Wine (www.winehq.org) and XQuartz (www.winehq.org ). Copyright (c) 1993-2017 the Wine project authors (see the file AUTHORS for a complete list). Wine is free software; you can redistribute it and/or modify it under the terms of the GNU Lesser General Public License as published by the Free Software Foundation. The XQuartz project is an open-source effort to develop a version of the X.Org X Window System that runs on OS X. Together with supporting libraries and applications, it forms the X11.app that Apple shipped with OS X versions 10.5 through 10.7.