An online version of the Action Potential Experiments simulation is available. The original simulation was published by the BioQUEST Curriculum Consortium, and is still available from this link at the BioQUEST site. That version runs only on Windows XP and earlier, and Mac OS9. However, using video screen capture technology, the online version will run on any device.
Action Potential Experiments is a demonstration/simulation laboratory for neurophysiology based on the “sodium theory” as originally formulated and tested by A. L. Hodgkin and his colleagues. It includes simulations of the original experiments of Hodgkins and Huxley, and of the classic voltage clamp and patch clamp experiments, as well as an animated illustration of the “sodium theory” explanation of Nernst potentials for potassium and sodium ions. The student can perform simple ion concentration experiments to test the predictions of the theory, similar to the experiments originally performed by Hodgkin and Huxley.
Check it out at http://www.caseitproject.org/action-potential-experiments/.
The Case It project is part of the Science Case Network (SCN), a community of educators using case studies and problem-based learning in science education. The network is funded by a National Science Foundation RCN-UBE grant. From the SCN site: The Science Case Network “supports an active community of science educators, learners, researchers, developers, and professional organizations interested in furthering the accessibility, development, and use of case studies and problem based learning (PBL) in science education.”
Visit the ScienceCaseNet site to join the community.
Collaborating Projects in the Science Case Network:
National Center for Case Study Teaching in Science: Clearinghouse for Case Studies in Science http://sciencecases.lib.buffalo.edu/cs/
PBL Clearinghouse: A collection of problems and articles to assist educators in using problem-based learning. https://primus.nss.udel.edu/Pbl/
More than fifty investigative lessons or “cases,” for K-12, undergraduate, and graduate science. Free registration enables you to download cases and support materials. http://www.cse.emory.edu/cases/
Investigative Case-Based Learning
Case modules developed by faculty participants in the Investigative Case-Based Learning workshops. http://bioquest.org/icbl/
Case It! was awarded an AAAS Science Prize for Inquiry-based Instruction (IBI). An essay describing the project was published in the July 27, 2012 issue of Science (“Engaging Students in Molecular Biology via Case-Based Learning“).
From the Science web site: “The Science Prize for Inquiry-Based Instruction (IBI) has been established to encourage innovation and excellence in education by recognizing outstanding, inquiry-based science and design-based engineering education modules. This type of education is a form of active learning wherein the instructor provides a question, or a challenge, and a general set of procedures that can be used to answer it. The students then produce an explanation or answer that is based on the evidence that they collect from appropriate resource materials or experimental processes that are, at least in part, of the students own proposal.”
More information is available in the press release from AAAS, and the editorial by Bruce Alberts, Editor in Chief of Science.
A new version of the Case It simulation (Case It v6.06) with microarray cases was released on January 28, 2012. The latest update was added on February 8. See the version history for information about each release.
Case It v6.06 includes SNP and expression microarray features, along with associated cases in cardiac disease, HIV resistance, breast cancer, prostate cancer, pharmacogenomics, and melanoma. New video tutorials in screencast format are available. We are in the process of converting all of the tutorials to video screencast format
The Student version of the Resource Manual has been updated to include the new case descriptions. Contact Mark Bergland to access the Instructor’s version of the manual, with keys to the cases and additional background information.
This release has not been thoroughly class tested, so please let us know if you encounter any difficulties.